The Adaptive NK Cell Response

EBI3 regulates the NK cell response to mouse cytomegalovirus infection.

Natural killer (NK) cells are key mediators in the control of cytomegalovirus infection. Here, we show that Epstein-Barr virus-induced 3 (EBI3) is expressed by human NK cells after NKG2D or IL-12 plus IL-18 stimulation and by mouse NK cells during mouse cytomegalovirus (MCMV) infection. The induction of EBI3 protein expression in mouse NK cells is a late activation event. Thus, early activation...

IL-2–dependent adaptive control of NK cell homeostasis

Activation and expansion of T and B lymphocytes and myeloid cells are controlled by Foxp3(+) regulatory T cells (T reg cells), and their deficiency results in a fatal lympho- and myeloproliferative syndrome. A role for T reg cells in the homeostasis of innate lymphocyte lineages remained unknown. Here, we report that T reg cells restrained the expansion of immature CD127(+) NK cells, which had ...

Cell Education NK Cell Differentiation Independently of NK Fever Virus 17D Is Primarily Governed by The Human NK Cell Response to Yellow

IFN type III: in vivo NK cell response

Despite extensive studies over the last decade reinforcing the role of the immune system in controlling cancer progression and inflammatory disorders, our knowledge of the innate immune system remains quite poor. Natural killer (NK) cells are naturally circulating innate lymphocytes that protect against both tumor development and infection. NK cells exert two major effector functions, the cytot...

The NK cell response to mouse cytomegalovirus infection affects the level and kinetics of the early CD8(+) T-cell response.

Natural killer (NK) cells and CD8(+) T cells play a prominent role in the clearance of mouse cytomegalovirus (MCMV) infection. The role of NK cells in modulating the CD8(+) T-cell response to MCMV infection is still the subject of intensive research. For analyzing the impact of NK cells on mounting of a CD8(+) T-cell response and the contribution of these cells to virus control during the first...